Scientific Articles

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, author, journal name or year published.

Clinical Research

November 2016

Adherence and Acceptability of a Multidrug Vaginal Ring for HIV Prevention in a Phase I Study in the United States

van der Straten A, Panther L, Laborde N, Hoesley CL, Cheng H, Husnik MJ, Horn S, Nel A, Soto-Torres L, Chen BA. AIDS and Behavior. 20, no. 11 (November 2016): 2644-2653.

July 2016

Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial

Dezzutti CS, Richardson-Harman N, Rohan L, Marzinke MA, Hoesley CJ, Panther L, Johnson S, Nuttall JP, Nel A, Chen BA. Medicine 95, no. 8 (2016 Jul): e4174. doi: 10.1097/MD.0000000000004174.

June 2016

Post-use assay of vaginal rings (VRs) as a potential measure of clinical trial adherence

Spence P, Nel A, van Niekerk N, Derrick T, Wilder S, Devlin B. Journal of Pharmaceutical and Biomedical Analysis. 125 (5 Jun 2016): 94-100.

March 2016

Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa

Nel A, Bekker LG, Bukusi E, Hellstrӧm, Kotze P, Louw C, Martinson F, Masenga G, Montgomery E, Ndaba N, van der Straten A, van Niekerk N, Woodsong C. PLOS ONE. 10 Mar 2016, doi: 10.1371/journal.pone....

November 2015

A Phase 1 trial to assess the safety, acceptability, pharmacokinetics and pharmacodynamics of a novel dapivirine vaginal film

Bunge KE, Dezzutti CS, Rohan LC, Hendrix CW, Marzinke MA, Richardson-Harman N, Moncla BJ, Devlin B, Meyn LA, Spiegel HML, Hillier SL. Journal of Acquired Immune Deficiency Syndromes. Epub 2015 Nov 11.

May 2015

Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics of Dapivirine and Maraviroc Vaginal Rings: a Double-Blind Randomized Trial

Chen BA, Panther L, Marzinke MA, Hendrix CW, Hoesley CJ, van der Straten A, Husnik MJ, Soto-Torres L, Nel A, Johnson S, Richardson-Harman, Rabe LK, Dezzutti CS. Journal of Acquired Immune Deficiency...

October 2014

Pharmacokinetics and Safety Assessment of Anti-HIV Dapivirine Vaginal Microbicide Rings with Multiple Dosing

Nel AM, Haazen W, Nuttall JP, Romano JW, Mesquita PMM, Herold BC, Rosenberg ZF, van Niekerk N. Journal of AIDS & Clinical Research. 5 (3 Oct 2014):355.

September 2014

Community and research staff collaboration for development of materials to inform microbicide study participants in Africa

Woodsong C, Mutsambi JM, Ntshele S, Modikoe P. JIAS. 17(Suppl 2):19156.

June 2014

A safety and pharmacokinetic trial assessing delivery of dapivirine from a vaginal ring in healthy women

Nel A, Haazen W, Nuttall J, Romano J, Rosenberg Z, van Niekerk N. AIDS. 28, no. 10 (June 19, 2014):1479-87.

February 2014

A Randomized Male Tolerance Study of Dapivirine Gel Following Multiple Topical Penile Exposures (MTN 012/IPM 010)

Cranston RD, Hoesley C, Carballo-Diéguez A, Hendrix CW, Husnik M, Levy L, Hall W, Soto-Torres L, Nel AM. AIDS Research and Human Retroviruses. 30, no. 2 (2014 Feb):184-9. Epub 2013 Oct 26.