Scientific Articles

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, author, journal name or year published.

Preclinical Research

June 2012

Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine.

das Neves J, Michiels J, Arien KK, Vanham G, Amiji M, Bahia MF, Sarmento B. Pharmaceutical Research. 29, no. 6 (June 2012): 1468-84. Epub 10 November 2011.

April 2012

Development of a Combination Microbicide Gel Formulation Containing IQP-0528 and Tenofovir for the Prevention of HIV Infection

Ham AS, Ugaonkar SR, Shi L, Buckheit KW, Lakougna H, Nagaraja U, Gwozdz G, Goldman L, Kiser PF, Buckheit RW Jr. Journal of Pharmaceutical Sciences. 101, no. 4 (April 2012):1423-35. Epub 6 Jan 2012.

January 2012

Pharmacokinetics of Tenofovir following Intravaginal and Intrarectal Administration of Tenofovir Gel to Rhesus Macaques.

Nuttall J, Kashuba A, Wang R, White N, Allen P, Robert J, Romano J. Antimicrobial Agents and Chemotherapy. 56, no. 1 (January 2012):103-9. Epub 10 October 2011.

June 2010

Development and validation of a rapid reversed-phase HPLC method for the determination of the non-nucleoside reverse transcriptase inhibitor dapivirine from polymeric nanoparticles.

das Neves J, Sarmento B, Amiji MM, Bahia MF. Journal of Pharmaceutical and Biomedical Analysis. 52, no. 2 (5 June 2010):167-72. Epub 2010 Jan 15.

March 2010

Freeze-dried, mucoadhesive system for vaginal delivery of the HIV microbicide, dapivirine: optimization by an artificial neural network.

Woolfson A.D., Umrethia M.L., Kett V.L., Malcolm R.K. International Journal of Pharmaceutics 388, no.1-2 (2010):136-143. 

February 2010

Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir.

Johnson T.J., Gupta K.M., Fabian J., Albrights T.H., Kiser P.F. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences 39, no. 4 (2010):...

February 2009

Inhibition of HIV-1 infection by the candidate microbicide, dapivirine, a nonnucleoside reverse transcriptase inhibitor.

Fletcher P., Harman S., Azijn H., Armanasco N., Manlow P., Perumal D., de Bethune M-P., Nuttall J., Romano J., Shattock R. Antimicrobial Agents and Chemotherapy 53, no. 2 (2009):487-95.

March 2008

Concentrations of dapivirine in the rhesus macaque and rabbit following once daily intravaginal administration of a gel formulation of [14C] dapivirine for 7 days.

Nuttall J.P., Thake D.C., Lewis M.G., Ferkany J.W., Romano J.W., Mitchnick M.A. Antimicrobial Agents and Chemotherapy 52, no. 3(2008) :909-14.

February 2005

Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development.

Colleluori D.M., Tien D., Kang F., Pagliei T., Kuss R., McCormick T., Watson K., McFadden K., Chaiken I., Buckheit R.W., Jr, Romano J.W. Protein Expression and Purification 39, no. 2 (2005): 229-36.

Clinical Research

December 2016

Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women

Nel A, van Niekerk N, Kapiga S, Bekker LG, Gama C, Gill K, Kamali A, Kotze P, Louw C, Mabude Z, Miti N, Kusemererwa S, Tempelman H, Carstens H, Devlin B, Isaacs M, Malherbe, Mans W, Nuttall J,...